1979•British Journal of PharmacologyOpen access

NALOXONE INHIBITS THE ANTI‐DIARRHOEAL ACTIVITY OF LOPERAMIDE

Montford F. Piercey, Mary J. Ruwart

Abstract

1 Subcutaneous prostaglandin E2 (2.5 mg/kg) produces profuse diarrhoea in fed rats. 2 Pretreatment of rats with subcutaneous loperamide (1.0 mg/kg) completely prevents prostaglandin-induced diarrhoea. If naloxone is administered prior to loperamide injections the activity of the antidiarrhoeal compound is completely destroyed. 3 These data provide strong evidence that the antidiarrhoeal activity of loperamide is mediated via the opiate receptor.

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Key concepts: Loperamide, Antidiarrhoeal, (+)-Naloxone, Opiate, Medicine, Pharmacology, Prostaglandin, Diarrhoeal disease