2008•European Journal of Cancer SupplementsRequires access

250 ORAL OXA-01, a novel potent mTORC1/TORC2 kinase inhibitor, demonstrates broad spectrum antitumor activity in preclinical models of human cancer

Prafulla C. Gokhale, Shripad V. Bhagwat, Andy Crew, Anne Cooke, Christine Mantis, Jennifer E. Workman, Darla Landfair, Mark Bittner, Jonathan A. Pachter, Robert Wild

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Key concepts: mTORC2, mTORC1, PI3K/AKT/mTOR pathway, P70-S6 Kinase 1, Protein kinase B, Programmed cell death, RPTOR, Neurotoxicity