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1967•EndocrinologyRequires access

Sensitivity to ADH of Normal and Diabetes Insipidus Rats1

Charles R. Kleeman, H. Vorherr, MAHMOUD HOUGHOUGHI

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Abstract

A group of diabetes insipidus (D.I.) rats and a control group of normal rats were anesthetized with 12% ethanol (5% of body weight) and injected with varying doses of arginine- vasopressin (AVP, bovine origin). Urine flow was monitored by means of an electric dropcounter. D.I. rats demonstrated increasingly greater sensitivity to 10 μU (p <0.2) and to 25 μU vasopressin (p<0.05) than did normal rats. No difference in sensitivity was noticeable between the 2 groups of rats for AVP doses of 2.5 and 5 μU (Endocrinology80: 1168, 1967)

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What this paper is about

A group of diabetes insipidus (D.I.) rats and a control group of normal rats were anesthetized with 12% ethanol (5% of body weight) and injected with varying doses of arginine- vasopressin (AVP, bovine origin). Urine flow was monitored by means of an electric dropcounter. D.I. rats demonstrated increasingly greater sensitivity to 10 μU (p <0.2) and to 25 μU vasopressin (p<0.05) than did normal rats. No difference in sensitivity was noticeable between the 2 groups of rats for AVP doses of 2.5 and 5 μU (Endocrinology80: 1168, 1967)

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Available abstract

A group of diabetes insipidus (D.I.) rats and a control group of normal rats were anesthetized with 12% ethanol (5% of body weight) and injected with varying doses of arginine- vasopressin (AVP, bovine origin). Urine flow was monitored by means of an electric dropcounter. D.I. rats demonstrated increasingly greater sensitivity to 10 μU (p <0.2) and to 25 μU vasopressin (p<0.05) than did normal rats. No difference in sensitivity was noticeable between the 2 groups of rats for AVP doses of 2.5 and 5 μU (Endocrinology80: 1168, 1967)

Key concepts: Internal medicine, Endocrinology, Diabetes insipidus, Vasopressin, Arginine, Chemistry, Urine, Medicine

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