1982•The Tohoku Journal of Experimental MedicineOpen access

A method for determination of human urinary inactive kallikrein (prekallikrein).

Kazuaki Shimamoto, Julie Chao, Harry S. Margolius

Abstract

SHIMAMOTO, K., CHAO, J. and MARGOLIUS, H.S. A Method for Determination of Human Urinary Inactive Kallikrein (Prekallikrein). Tohoku J. exp. Med., 1982, 137 (3), 269-274-Inactive kallikrein (prekallikrein) in human urine was discovered recently. A more accurate method to measure this zymogen and total kallikrein is described. With trypsin pretreatment, it was found that 35.3±2.7% of total urinary kallikrein activity was prekallikrein. The results are supported by a new direct radioimmunoassay which measures predominantly active kallikrein.

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Key concepts: Prekallikrein, Kallikrein, Urinary system, Chemistry, Biochemistry, Endocrinology, Medicine, Enzyme