Gary M. Coppola, Robert E. Damon
Abstract
Abstract The reaction of 4,4‐dimethyl‐3‐oxobutanoic (or pentanoic) acid esters with the lactim ether of 2‐pyrrolidone in the presence of 2‐hydroxypyridine produces condensation products 4 in 57–72% yield. Acidic hydrolysis of 4 affords the furandione system 5 in 75–81% yield.
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Abstract The reaction of 4,4‐dimethyl‐3‐oxobutanoic (or pentanoic) acid esters with the lactim ether of 2‐pyrrolidone in the presence of 2‐hydroxypyridine produces condensation products 4 in 57–72% yield. Acidic hydrolysis of 4 affords the furandione system 5 in 75–81% yield.
Key concepts: Chemistry, Yield (engineering), Hydrolysis, Ether, Condensation, Organic chemistry, Dimethyl ether, Acid hydrolysis