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1986•Scandinavian Journal of GastroenterologyRequires access

The Effect of Omeprazole on Acid and Pepsin Secretion in Duodenal Ulcer Patients

J. A. Wilson, E. J. S. Boyd, K. G. Wormsley

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Abstract

Studies in humans have shown that omeprazole produces a dose dependent and long lasting inhibition of pentagastrin stimulated and overnight acid secretion (1). In studies of patients with duodenal ulcer, where doses of 20, 30, 40 or 60 mg daily were given for 28 days, the compound has been well tolerated (2). It was of interest, therefore, to compare secretory inhibition in duodenal ulcer patients and normal subjects using the same technique.

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What this paper is about

Studies in humans have shown that omeprazole produces a dose dependent and long lasting inhibition of pentagastrin stimulated and overnight acid secretion (1). In studies of patients with duodenal ulcer, where doses of 20, 30, 40 or 60 mg daily were given for 28 days, the compound has been well tolerated (2). It was of interest, therefore, to compare secretory inhibition in duodenal ulcer patients and normal subjects using the same technique.

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Available abstract

Studies in humans have shown that omeprazole produces a dose dependent and long lasting inhibition of pentagastrin stimulated and overnight acid secretion (1). In studies of patients with duodenal ulcer, where doses of 20, 30, 40 or 60 mg daily were given for 28 days, the compound has been well tolerated (2). It was of interest, therefore, to compare secretory inhibition in duodenal ulcer patients and normal subjects using the same technique.

Key concepts: Omeprazole, Pepsin, Pentagastrin, Duodenal ulcer, Gastroenterology, Internal medicine, Secretion, Gastric acid

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