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1981•Archives of Disease in ChildhoodOpen access

Bronchodilator effects of clemastine, ipratropium, bromide, and salbutamol in preschool children with asthma.

R C Groggins, Anthony Milner, G M Stokes

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Abstract

The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.

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The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.

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Available abstract

The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.

Key concepts: Ipratropium bromide, Salbutamol, Medicine, Bronchodilator, Bronchodilation, Ipratropium, Bronchodilator Agents, Anesthesia

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Bronchodilator effects of clemastine, ipratropium, bromide, and salbutamol in preschool children with asthma. — Research Paper | ScholarLens