2005•Applied and Environmental MicrobiologyOpen access

Transcriptional Analysis of Genes Encoding Shiga Toxin 2 and Its Variants in Escherichia coli

Wenlan Zhang, Martina Bielaszewska, Alexander W. Friedrich, Thorsten Kuczius, Helge Karch

Abstract

Six of 37 non-O157 Escherichia coli strains possessing Shiga toxin (Stx) 2 gene variant stx(2d) or stx(2e) secreted no detectable Stx. These isolates produced significantly less stx mRNA than Stx2d, Stx2e, Stx2c, or Stx2 secretors did. Standard screening procedures miss a significant subset of E. coli harboring stx(2) variants.

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Key concepts: Shiga toxin, Escherichia coli, STX2, Biology, Shiga-like toxin, Microbiology, Gene, Enterobacteriaceae