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Trigeminal neuralgia

Richard B. Tenser

Open publisher page 60 citations

Abstract

BACKGROUND: Mechanisms of the surgical treatment of trigeminal neuralgia are considered. RESULTS: Trigeminal neuralgia is effectively treated by microvascular decompression (MVD) and other surgical procedures. These procedures often cause reactivation of herpes simplex virus (HSV), which is latent in trigeminal ganglion neurons. CONCLUSION: MVD and other surgical procedures alter ganglion neuron transcription, as indicated by HSV reactivation. Controlled injury of the trigeminal root-ganglion probably occurs with the disparate surgical procedures, and this is likely the means of their effectiveness.

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What this paper is about

BACKGROUND: Mechanisms of the surgical treatment of trigeminal neuralgia are considered. RESULTS: Trigeminal neuralgia is effectively treated by microvascular decompression (MVD) and other surgical procedures. These procedures often cause reactivation of herpes simplex virus (HSV), which is latent in trigeminal ganglion neurons. CONCLUSION: MVD and other surgical procedures alter ganglion neuron transcription, as indicated by HSV reactivation. Controlled injury of the trigeminal root-ganglion probably occurs with the disparate surgical procedures, and this is likely the means of their effectiveness.

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Available abstract

BACKGROUND: Mechanisms of the surgical treatment of trigeminal neuralgia are considered. RESULTS: Trigeminal neuralgia is effectively treated by microvascular decompression (MVD) and other surgical procedures. These procedures often cause reactivation of herpes simplex virus (HSV), which is latent in trigeminal ganglion neurons. CONCLUSION: MVD and other surgical procedures alter ganglion neuron transcription, as indicated by HSV reactivation. Controlled injury of the trigeminal root-ganglion probably occurs with the disparate surgical procedures, and this is likely the means of their effectiveness.

Key concepts: Trigeminal neuralgia, Trigeminal ganglion, Microvascular decompression, Medicine, Ganglion, Herpes simplex virus, Neuralgia, Trigeminal nerve

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