2014•Journal of Investigative and Clinical DentistryRequires access
Expression of key executioner of apoptosis caspase‐3 in periodontal health and disease
A.R. Pradeep, Deepak Kumar Suke, M. Prasad, Sonender Pal Singh, Santosh Martande, Kanika Nagpal, Savitha B. Naik, C. N. Guruprasad, Arjun Raju, Priyanka Singh, Math Siddaya
Open publisher page 46 citations
Abstract
AIM: A highly-regulated form of programmed cell death is apoptosis, and its perturbation has been associated with periodontal disease. Caspase-3 is one of the key executioners of apoptosis. The present study was designed to evaluate and correlate the levels of caspase-3 in gingival crevicular fluid (GCF) and serum in participants with clinically-healthy periodontium, gingivitis, and chronic periodontitis (CP). METHODS: Forty-four sex- and age-matched participants were enrolled into three groups based on clinical parameters. Group 1 participants had clinically-healthy periodontium, group 2 participants had gingivitis, and group 3 participants had CP. GCF and serum samples were collected to evaluate the levels of caspase-3. RESULTS: The mean caspase-3 concentration in GCF and serum was highest in group 3, followed by group 2, and was significantly correlated with gingival index, probing depth (PD), and clinical attachment level (CAL). CONCLUSION: GCF and the serum concentration of caspase-3 proportionally increases with the progression of periodontal disease, that is, gingival inflammation, PD, and CAL.