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1977•The Journal of Clinical Endocrinology & MetabolismRequires access

GLUCOSE, INSULIN AND SOMATOSTATIN INFUSION FOR THE DETERMINATION OF INSULIN SENSITIVITY

Y. Harano, S Ohgaku, Hideki Hidaka, Kentaro Haneda, Ryuichi Kikkawa, Y. Shigeta, Hiroshi Abe

Open publisher page 151 citations

Abstract

Glucose, insulin and somatostatin infusion over 2 hours effectively suppressed endogenous secretion of insulin, glucagon and growth hormones. Steady state plasma glucose level (SSPG) which should be inversely proportional to insulin sensitivity was obtained. In 6 adult-onset non-obese untreated diabetics, mean value of insulin sensitivity indices was significantly reduced compared with normal. In 5 insulin-treated diabetics and in 5 subjects with borderline glucose tolerance including 2 obese subjects, insulin sensitivity for glucose utilization was also significantly diminished.

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What this paper is about

Glucose, insulin and somatostatin infusion over 2 hours effectively suppressed endogenous secretion of insulin, glucagon and growth hormones. Steady state plasma glucose level (SSPG) which should be inversely proportional to insulin sensitivity was obtained. In 6 adult-onset non-obese untreated diabetics, mean value of insulin sensitivity indices was significantly reduced compared with normal. In 5 insulin-treated diabetics and in 5 subjects with borderline glucose tolerance including 2 obese subjects, insulin sensitivity for glucose utilization was also significantly diminished.

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OpenAlex reports 151 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Glucose, insulin and somatostatin infusion over 2 hours effectively suppressed endogenous secretion of insulin, glucagon and growth hormones. Steady state plasma glucose level (SSPG) which should be inversely proportional to insulin sensitivity was obtained. In 6 adult-onset non-obese untreated diabetics, mean value of insulin sensitivity indices was significantly reduced compared with normal. In 5 insulin-treated diabetics and in 5 subjects with borderline glucose tolerance including 2 obese subjects, insulin sensitivity for glucose utilization was also significantly diminished.

Key concepts: Internal medicine, Somatostatin, Endocrinology, Insulin, Glucagon, Insulin sensitivity, Medicine, Hormone

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