ScholarLens Back to search
1995•Journal of Antimicrobial ChemotherapyRequires access

Comparing antimicrobial activity against resistant Pseudomonas aeruginosa using an index for the absence of cross-resistance

Keiichi Takigawa, Jiro Fujita, Kiyoshi Negayama, Guang Xu, Yoshifumi Yamagishi, Hiroshi Miyawaki, Satoko Hojo, Yasufumi Yamaji, Jiro Takahara

Open publisher page 6 citations

Abstract

We devised an index to estimate the degree cross-resistance between piperacillin, ceftazidime, sulbactam/cefoperazone, amikacin, tobramycin, carumonam and imipenem against 139 separate clinical isolates of Pseudomonas aeruginosa. A negative value of the index indicated the cross-resistance whereas a positive value suggested the converse making the device an index for the absence of cross resistance (ACR). Using the ACR index, we identified pairs of antibiotics exhibiting the least degree of cross-resistance and therefore the highest potential for treating infections due to P. aeruginosa.

About this research paper

What this paper is about

We devised an index to estimate the degree cross-resistance between piperacillin, ceftazidime, sulbactam/cefoperazone, amikacin, tobramycin, carumonam and imipenem against 139 separate clinical isolates of Pseudomonas aeruginosa. A negative value of the index indicated the cross-resistance whereas a positive value suggested the converse making the device an index for the absence of cross resistance (ACR). Using the ACR index, we identified pairs of antibiotics exhibiting the least degree of cross-resistance and therefore the highest potential for treating infections due to P. aeruginosa.

Why it matters

OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

We devised an index to estimate the degree cross-resistance between piperacillin, ceftazidime, sulbactam/cefoperazone, amikacin, tobramycin, carumonam and imipenem against 139 separate clinical isolates of Pseudomonas aeruginosa. A negative value of the index indicated the cross-resistance whereas a positive value suggested the converse making the device an index for the absence of cross resistance (ACR). Using the ACR index, we identified pairs of antibiotics exhibiting the least degree of cross-resistance and therefore the highest potential for treating infections due to P. aeruginosa.

Key concepts: Tobramycin, Pseudomonas aeruginosa, Amikacin, Cefoperazone, Ceftazidime, Sulbactam, Piperacillin, Microbiology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Comparing antimicrobial activity against resistant Pseudomonas aeruginosa using an index for the absence of cross-resistance — Research Paper | ScholarLens