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2014•Atlas of Genetics and Cytogenetics in Oncology and HaematologyOpen access

DLX5 (distal-less homeobox 5)

Yorick Gitton, Giovanni Levi

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Abstract

DLX5 belongs to the six-member family of DLX genes characterized by a homeobox related to that found in the insect Distal-less (Dll) gene.The six DLX genes are organized as three bigenic pairs with a tail-to-tail orientation (Zerucha et al., 2000) and located on chromosomes where HOX clusters are also found (DLX5/DLX6; 7q21.3,syntenic to the HOXA cluster), (DLX1/DLX2; 2q32, syntenic to the HOXD cluster; Simeone et al., 1994) and (DLX3/DLX4; 17q21.33,syntenic to the HOXB cluster).During embryonic development DLX genes are involved in the control of appendage and craniofacial morphogenesis and in the differentiation of reproductive organs; in the adult they play a role in bone homeostasis and in the maintenance of tissue integrity.

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DLX5 belongs to the six-member family of DLX genes characterized by a homeobox related to that found in the insect Distal-less (Dll) gene.The six DLX genes are organized as three bigenic pairs with a tail-to-tail orientation (Zerucha et al., 2000) and located on chromosomes where HOX clusters are also found (DLX5/DLX6; 7q21.3,syntenic to the HOXA cluster), (DLX1/DLX2; 2q32, syntenic to the HOXD cluster; Simeone et al., 1994) and (DLX3/DLX4; 17q21.33,syntenic to the HOXB cluster).During embryonic development DLX genes are involved in the control of appendage and craniofacial morphogenesis and in the differentiation of reproductive organs; in the adult they play a role in bone homeostasis and in the maintenance of tissue integrity.

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Available abstract

DLX5 belongs to the six-member family of DLX genes characterized by a homeobox related to that found in the insect Distal-less (Dll) gene.The six DLX genes are organized as three bigenic pairs with a tail-to-tail orientation (Zerucha et al., 2000) and located on chromosomes where HOX clusters are also found (DLX5/DLX6; 7q21.3,syntenic to the HOXA cluster), (DLX1/DLX2; 2q32, syntenic to the HOXD cluster; Simeone et al., 1994) and (DLX3/DLX4; 17q21.33,syntenic to the HOXB cluster).During embryonic development DLX genes are involved in the control of appendage and craniofacial morphogenesis and in the differentiation of reproductive organs; in the adult they play a role in bone homeostasis and in the maintenance of tissue integrity.

Key concepts: DLX5, Homeobox, Hox gene, Biology, Homeobox protein Nkx-2.5, Morphogenesis, Synteny, HNF1B

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