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Influence of Brain Neurohumors Injected Into the Lateral Ventricle of the Rat on Growth Hormone Release

Eugenio E. Müller, P. Dal Pra, Antonio Pecile

Open publisher page 60 citations

Abstract

Epinephrine (0.5 μg), norepinephrine (0.5 and 0.1 μg) and dopamine (0.5 and 0.1 μg) when injected into the lateral ventricle of the rat brain, induced a depletion of growth hormone (GH) pituitary content. Unlike adrenergic compounds, other physiological constituents of hypothalamic tissue, i.e., serotonin (0.5 μg), acetylcholine (0.5 μg), vasopressin (8 mU) and oxytocin (8 mU) did not show any GHreleasing activity when given by intraventricular route. The effect of epinephrine, norepinephrine and dopamine appeared to be unrelated to changes of blood glucose or body temperature. These results support the view that adrenergic mediators participate in the neurohumoral control of GH secretion. (Endocrinology83: 893, 1968)

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What this paper is about

Epinephrine (0.5 μg), norepinephrine (0.5 and 0.1 μg) and dopamine (0.5 and 0.1 μg) when injected into the lateral ventricle of the rat brain, induced a depletion of growth hormone (GH) pituitary content. Unlike adrenergic compounds, other physiological constituents of hypothalamic tissue, i.e., serotonin (0.5 μg), acetylcholine (0.5 μg), vasopressin (8 mU) and oxytocin (8 mU) did not show any GHreleasing activity when given by intraventricular route. The effect of epinephrine, norepinephrine and dopamine appeared to be unrelated to changes of blood glucose or body temperature. These results support the view that adrenergic mediators participate in the neurohumoral control of GH secretion. (Endocrinology83: 893, 1968)

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Available abstract

Epinephrine (0.5 μg), norepinephrine (0.5 and 0.1 μg) and dopamine (0.5 and 0.1 μg) when injected into the lateral ventricle of the rat brain, induced a depletion of growth hormone (GH) pituitary content. Unlike adrenergic compounds, other physiological constituents of hypothalamic tissue, i.e., serotonin (0.5 μg), acetylcholine (0.5 μg), vasopressin (8 mU) and oxytocin (8 mU) did not show any GHreleasing activity when given by intraventricular route. The effect of epinephrine, norepinephrine and dopamine appeared to be unrelated to changes of blood glucose or body temperature. These results support the view that adrenergic mediators participate in the neurohumoral control of GH secretion. (Endocrinology83: 893, 1968)

Key concepts: Endocrinology, Internal medicine, Epinephrine, Norepinephrine, Vasopressin, Dopamine, Oxytocin, Ventricle

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