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1992•Antimicrobial Agents and ChemotherapyOpen access

Use of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS

Alison J. Berry, Michael G. Rinaldi, John R. Graybill

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Abstract

Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.

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What this paper is about

Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.

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OpenAlex reports 81 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.

Key concepts: Fluconazole, Cryptococcal meningitis, Medicine, Meningitis, Salvage therapy, Antifungal, Mycosis, Internal medicine

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