ScholarLens Back to search
1965•British Journal of RadiologyRequires access

The Effect of Fractionation on Four Day Survival of Mice after Whole-body Neutron Irradiation

Shirley Hornsey, S. Vatistas, David Kevin Bewley, C. J. Parnell

Open publisher page 41 citations

Abstract

The proportion of animals surviving four days after whole body neutron irradiation is not altered by giving the radiation in two fractions separated by four to six hours. This result is compared with previously reported data after 250 kV X irradiation when it was found that a dose higher by 400–600 rads was necessary to produce the same killing effect if the radiation was given in two fractions rather than a single dose. This results in a larger RBE (250 kV/neutron) for the fractioned radiation than for single-dose irradiation and any increase in the number of fractions would increase the RBE further. These results may be relevant to the use of neutrons for therapy.

About this research paper

What this paper is about

The proportion of animals surviving four days after whole body neutron irradiation is not altered by giving the radiation in two fractions separated by four to six hours. This result is compared with previously reported data after 250 kV X irradiation when it was found that a dose higher by 400–600 rads was necessary to produce the same killing effect if the radiation was given in two fractions rather than a single dose. This results in a larger RBE (250 kV/neutron) for the fractioned radiation than for single-dose irradiation and any increase in the number of fractions would increase the RBE further. These results may be relevant to the use of neutrons for therapy.

Why it matters

OpenAlex reports 41 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The proportion of animals surviving four days after whole body neutron irradiation is not altered by giving the radiation in two fractions separated by four to six hours. This result is compared with previously reported data after 250 kV X irradiation when it was found that a dose higher by 400–600 rads was necessary to produce the same killing effect if the radiation was given in two fractions rather than a single dose. This results in a larger RBE (250 kV/neutron) for the fractioned radiation than for single-dose irradiation and any increase in the number of fractions would increase the RBE further. These results may be relevant to the use of neutrons for therapy.

Key concepts: Irradiation, Nuclear medicine, Fractionation, Whole body irradiation, Neutron irradiation, Neutron, Relative biological effectiveness, Radiochemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Effect of Fractionation on Four Day Survival of Mice after Whole-body Neutron Irradiation — Research Paper | ScholarLens