2007•Anesthesia ProgressOpen access

The Recognition, Physiology, and Treatment of Medication-Induced Methemoglobinemia: A Case Report

Michael D. Turner, Vasiliki Karlis, Robert S Glickman

Abstract

Dapsone is a leprostatic agent commonly prescribed for the management of leprosy, malaria, and the immunosuppression-induced infections of Pneumocystis carinii and Toxoplasma gondii. In susceptible patients, methemoglobinemia, a potentially life-threatening event, can occur. We report a case of dapsone-induced methemoglobinemia which was observed during general anesthesia for the management of a fractured mandible. The pathophysiology, diagnosis, and management of dapsone-induced methemoglobinemia will be discussed.

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Key concepts: Dapsone, Methemoglobinemia, Medicine, Pneumocystis carinii, Immunosuppression, Leprosy, Dermatology, Intensive care medicine