1996•GenomicsOpen access
Mapping of Unconventional Myosins in Mouse and Human
Tama Hasson, Joseph F. Skowron, Debra J. Gilbert, Karen B. Avraham, William L. Perry, William M. Bement, Blake Anderson, Elliott H. Sherr, Zheng‐Yi Chen, Lloyd A. Greene, David C. Ward, David P. Corey, Mark S. Mooseker, Neal G. Copeland, Nancy A. Jenkins
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Abstract
Myosins are molecular motors that move along filamentous actin. Seven classes of myosin are expressed in vertebrates: conventional myosin, or myosin-II, as well as the 6 unconventional myosin classes-I, -V, -VI, -VII, -IX, and -X. We have mapped in mouse 22 probes encompassing all known unconventional myosins and, as a result, have identified 16 potential unconventional myosin genes. These genes include 7 myosins-I, 2 myosins-V, 1 myosin-VI, 3 myosins-VII, 2 myosins-IX, and 1 myosin-X. The map location of 5 of these genes was identified in human chromosomes by fluorescence in situ hybridization.
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