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OCULAR INVOLVEMENT IN WHIPPLEʼS DISEASE

Evan J. Selsky, David L. Knox, A. Edward Maumenee, W. Richard Green

Open publisher page 39 citations

Abstract

A 60-year-old white man with recurrent nondeforming arthritis and no intestinal symptoms developed bilateral vitreous opacities strongly suggestive of Whipple's disease. He was successfully treated with tetracycline and erythromycin. Thirteen years later, a presumed diagnosis of Whipple's disease was established by histopathologic observation of macrophages that were distended by periodic acid-Schiff-positive material and the finding of bacilli by electron microscopy in a vitreous aspirate. The characteristics of ocular involvement in Whipple's disease are discussed.

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What this paper is about

A 60-year-old white man with recurrent nondeforming arthritis and no intestinal symptoms developed bilateral vitreous opacities strongly suggestive of Whipple's disease. He was successfully treated with tetracycline and erythromycin. Thirteen years later, a presumed diagnosis of Whipple's disease was established by histopathologic observation of macrophages that were distended by periodic acid-Schiff-positive material and the finding of bacilli by electron microscopy in a vitreous aspirate. The characteristics of ocular involvement in Whipple's disease are discussed.

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Available abstract

A 60-year-old white man with recurrent nondeforming arthritis and no intestinal symptoms developed bilateral vitreous opacities strongly suggestive of Whipple's disease. He was successfully treated with tetracycline and erythromycin. Thirteen years later, a presumed diagnosis of Whipple's disease was established by histopathologic observation of macrophages that were distended by periodic acid-Schiff-positive material and the finding of bacilli by electron microscopy in a vitreous aspirate. The characteristics of ocular involvement in Whipple's disease are discussed.

Key concepts: Whipple's disease, Whipple Disease, Medicine, Tropheryma whipplei, Pathology, Disease, Intestinal malabsorption, Coeliac disease

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