Two cases of γD Myeloma‡

Summary: The clinical and immunological features of 2 cases of γD myeloma are compared with other reported cases of γD myeloma and other types of multiple myeloma. Both cases showed extra-medullary plasmacytoma which has recently been described as a frequent finding in γD myeloma but which is unusual in other types of multiple myeloma. Bence Jones proteinuria was present in both cases. This is in line with the higher incidence in γD myeloma compared with other types of multiple myeloma. Immunoelectrophoresis showed one case with the more typical L type light chain, the other with the less common K type. Serum levels of the γD paraprotein were low in both instances, reflecting the higher catabolic rate of γD immunoglobulin.