1997•Journal of Heterocyclic ChemistryRequires access
Synthesis of dithia‐ and tetrathiacyclophanes incorporating isoxazole units
Taizo Hatta, Muneob Kawano, Hironori Maeda, Otohiko Tsuge
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Abstract
Abstract The reaction of 5‐bromomethyl‐3‐(p‐bromomethylphenyl)isoxazole with o‐, m‐, and p‐bis(mercap‐tomethyl)benzenes gave the corresponding dithia‐ and/or tetrathiaisoxazolophanes, whose relative yields strongly depended upon the nature of the mercaptomethyl compound. The above isoxazole dibromide reacted with the bis(mercaptomethyl)isoxazole to afford a mixture of two isomeric dithiaisoxazolophanes.