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Paraproteins and bence jones protein

E. N. Wardle

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Abstract

BJDIfURNALtions revealed that he is an alkaptonuric with moderate diabetes mellitus.The presence in his urine of homogentisic acid is confirmed by extraction' and chromato- graphic identification,2 and of glucose by osazone and Selivanoff's tests.Curiously enough, Clinistix failed to detect glucose in this urine.Further investigation has brought to light that this failure of Clinistix was due to the inhibition of peroxidase reaction by homogentisic acid.3This case seems to be the second to be reported from India since that of Bose et al.4where diabetes mellitus and alkaptonuria are coexistent.-Weare, etc., B. NAGANNA.

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BJDIfURNALtions revealed that he is an alkaptonuric with moderate diabetes mellitus.The presence in his urine of homogentisic acid is confirmed by extraction' and chromato- graphic identification,2 and of glucose by osazone and Selivanoff's tests.Curiously enough, Clinistix failed to detect glucose in this urine.Further investigation has brought to light that this failure of Clinistix was due to the inhibition of peroxidase reaction by homogentisic acid.3This case seems to be the second to be reported from India since that of Bose et al.4where diabetes mellitus and alkaptonuria are coexistent.-Weare, etc., B. NAGANNA.

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Available abstract

BJDIfURNALtions revealed that he is an alkaptonuric with moderate diabetes mellitus.The presence in his urine of homogentisic acid is confirmed by extraction' and chromato- graphic identification,2 and of glucose by osazone and Selivanoff's tests.Curiously enough, Clinistix failed to detect glucose in this urine.Further investigation has brought to light that this failure of Clinistix was due to the inhibition of peroxidase reaction by homogentisic acid.3This case seems to be the second to be reported from India since that of Bose et al.4where diabetes mellitus and alkaptonuria are coexistent.-Weare, etc., B. NAGANNA.

Key concepts: Paraproteins, Bence Jones protein, Chemistry, Immunoglobulin light chain, Biology, Antibody, Genetics, Monoclonal

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