2014•Chemical CommunicationsRequires access
The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin–heparin complex
Kwon Joo Yeo, Eunha Hwang, Kyong-Mi Min, Jun-Goo Jee, Chung-Kyung Lee, Kwang Yeon Hwang, Young Ho Jeon, Soo‐Ik Chang, Hae‐Kap Cheong
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Abstract
The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.