2009•The Pediatric Infectious Disease JournalOpen access

Pertussis Vaccine

John B. Robbins, Rachel Schneerson, Jerry M. Keith, Mark A. Miller, Joanna Kübler-Kiełb, Birger Trollfors

Abstract

A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.

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Key concepts: Filamentous haemagglutinin adhesin, Pertactin, Pertussis toxin, Bordetella pertussis, Herd immunity, Immunity, Whooping cough, Virology