1977•EndocrinologyRequires access

Evidence for a Role of α-Adrenergic Mechanisms in Regulation of Episodic Growth Hormone Secretion in the Rat

D. Durand, Joseph B. Martin, Paul Brazeau

Abstract

The role of catecholamines in regulation of episodic GH secretion was investigated in the male rat. Administration of alpha-methyl-p-tyrosine (alpha-MT; 250 mg/kg ip) caused significant suppression of GH bursts and resulted in marked elevation of plasma PRL. Intravenous administration of apomorphine (.03 and .1 mg/kg) had no effect on decreased GH levels, whereas clonidine (150 micrograms/kg) restored GH secretion. Apomorphine significantly reduced PRL levels in alpha-MT-treated rats whereas, clonidine resulted in a further increase in PRL.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 95 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Endocrinology, Internal medicine, Secretion, Adrenergic, Growth hormone, Hormone, Biology, Medicine