Detection of Biological Activities of Wild Mushroom Methanol Extracts

본 연구는 야생버섯으로부터 혈관계질환 관련 생리활성을 확인하여 혈관계질환을 위한 기능성식품 개발에 재료로 사용하기 위해 야생버섯 33종의 야생버섯 메탄올 추출물을 제조하여 심혈관계 질환 생리활성을 확인하였다. 긴대밤그물버섯(Boletellus elatus)과 벽돌빛뿌리버섯(Heterobasidion insulasis)이 높은 혈전용해 활성과 트롬빈저해효과, 항산화활성을 나타내 혈관계질환 치료나 예방을 위한 기능성식품 개발에 이용 가능할 것으로 기대된다. In this study, the biological activities of 33 kinds of wild mushroom methanol extracts were investigated. Boletellus elatus showed the greatest fibrinolytic activity (1.08 plasmin units/mL) in a fibrin plate assay, and the activity of Heterobasidion insulasis was 0.89 plasmin units. The thrombin inhibitory activities of Boletellus elatus and Heterobasidion insulasis were 93.32% and 93.69%, respectively. In a ${\alpha}$ -glucosidase inhibitory activity test, Laccaria amethystina showed the greatest inhibitory activity at 81.25%. The antioxidative activities of Gomphus sp. and Geastrum lageniforme were 91.37% and 90.42%, respectively. Since Boletellus elatus and Heterobasidion insulasis have strong fibrinolytic and thrombin inhibitory and antioxidative activities, the two mushrooms can be used as material for the development of biofunctional foods for cardiovascular diseases.