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2007•Pediatric Blood & CancerRequires access

Treatment of wild‐type gastrointestinal stromal tumor (WT‐GIST) with imatinib and sunitinib

Matthew Jonathan Murray, Helen M. Hatcher, Flora A. Jessop, Denise Williams, Nicholas R. Carroll, Ramesh Bulusu, Ian Robert Judson

Open publisher page 14 citations

Abstract

We report a rare case of advanced, metastatic gastrointestinal stromal tumor (GIST) in a young female. Molecular analysis of the tumor revealed wild-type (WT) KIT and platelet derived growth factor receptor alpha (PDGFRA) gene status with no mutations characteristic of adult GIST. Despite this she had clinical benefit and evidence of radiological response to sequential treatment with the tyrosine kinase inhibitors imatinib and sunitinib.

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What this paper is about

We report a rare case of advanced, metastatic gastrointestinal stromal tumor (GIST) in a young female. Molecular analysis of the tumor revealed wild-type (WT) KIT and platelet derived growth factor receptor alpha (PDGFRA) gene status with no mutations characteristic of adult GIST. Despite this she had clinical benefit and evidence of radiological response to sequential treatment with the tyrosine kinase inhibitors imatinib and sunitinib.

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OpenAlex reports 14 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We report a rare case of advanced, metastatic gastrointestinal stromal tumor (GIST) in a young female. Molecular analysis of the tumor revealed wild-type (WT) KIT and platelet derived growth factor receptor alpha (PDGFRA) gene status with no mutations characteristic of adult GIST. Despite this she had clinical benefit and evidence of radiological response to sequential treatment with the tyrosine kinase inhibitors imatinib and sunitinib.

Key concepts: Sunitinib, PDGFRA, GiST, Medicine, Imatinib, Stromal tumor, Tyrosine-kinase inhibitor, Imatinib mesylate

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Treatment of wild‐type gastrointestinal stromal tumor (WT‐GIST) with imatinib and sunitinib — Research Paper | ScholarLens