ScholarLens Back to search
2012•ApmisRequires access

The expression and significance of WWOX and β‐catenin in hepatocellular carcinoma

Yu‐Pu Li, Chun‐Chieh Wu, Wan‐Tzu Chen, Ya‐Chun Huang, Chee‐Yin Chai

Open publisher page 17 citations

Abstract

WW domain-containing oxidoreductase (WWOX) is a novel tumor suppressor gene, and its expression is reduced in various cancers, including hepatocellular carcinoma (HCC). WWOX has been reported to be downregulated in HCC cell lines as well as in primary HCC tissues. It has been suggested that WWOX is implicated in Wnt/β-catenin pathway, which is frequently affected in HCC. The aim of this study was to evaluate the expression of WWOX, β-catenin and T-cell factor 4 (TCF4) in HCC. Our result showed that downregulation of WWOX in HCC was correlated with cytoplasmic accumulation of β-catenin. In addition, strong nuclear TCF4 expression was associated with tumor grade and stage in HCC. In conclusion, our result implied that downregulation of WWOX might lead to accumulation of cytoplasmic β-catenin and the subsequent activation of Wnt/β-catenin signaling pathway in HCC.

About this research paper

What this paper is about

WW domain-containing oxidoreductase (WWOX) is a novel tumor suppressor gene, and its expression is reduced in various cancers, including hepatocellular carcinoma (HCC). WWOX has been reported to be downregulated in HCC cell lines as well as in primary HCC tissues. It has been suggested that WWOX is implicated in Wnt/β-catenin pathway, which is frequently affected in HCC. The aim of this study was to evaluate the expression of WWOX, β-catenin and T-cell factor 4 (TCF4) in HCC. Our result showed that downregulation of WWOX in HCC was correlated with cytoplasmic accumulation of β-catenin. In addition, strong nuclear TCF4 expression was associated with tumor grade and stage in HCC. In conclusion, our result implied that downregulation of WWOX might lead to accumulation of cytoplasmic β-catenin and the subsequent activation of Wnt/β-catenin signaling pathway in HCC.

Why it matters

OpenAlex reports 17 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

WW domain-containing oxidoreductase (WWOX) is a novel tumor suppressor gene, and its expression is reduced in various cancers, including hepatocellular carcinoma (HCC). WWOX has been reported to be downregulated in HCC cell lines as well as in primary HCC tissues. It has been suggested that WWOX is implicated in Wnt/β-catenin pathway, which is frequently affected in HCC. The aim of this study was to evaluate the expression of WWOX, β-catenin and T-cell factor 4 (TCF4) in HCC. Our result showed that downregulation of WWOX in HCC was correlated with cytoplasmic accumulation of β-catenin. In addition, strong nuclear TCF4 expression was associated with tumor grade and stage in HCC. In conclusion, our result implied that downregulation of WWOX might lead to accumulation of cytoplasmic β-catenin and the subsequent activation of Wnt/β-catenin signaling pathway in HCC.

Key concepts: WWOX, Downregulation and upregulation, Wnt signaling pathway, Hepatocellular carcinoma, Cancer research, Catenin, Suppressor, Beta-catenin

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The expression and significance of WWOX and β‐catenin in hepatocellular carcinoma — Research Paper | ScholarLens