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Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects.

Neil Barnes, Priscilla J. Piper, John Costello

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Abstract

The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.

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The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.

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Available abstract

The comparative actions of inhaled leukotriene C4 (LTC4), leukotriene D4 (LTD4), and histamine were studied in six normal subjects. LTC4 and LTD4 were shown to be more potent bronchoconstrictors than histamine, with a more sustained action. LTC4 and LTD4 caused wheezing without cough or throat irritation and were shown to act on large and small airways.

Key concepts: Leukotriene C4, Histamine, Leukotriene D4, Leukotriene, Medicine, Leukotriene E4, Montelukast, Pharmacology

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Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. — Research Paper | ScholarLens