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2014•The Journal of Headache and PainOpen access

EHMTI-0222. Habituation of visual evoked potentials in migraine: comparison between blinded and non-blinded analyses

Anna Ambrosini, Jean E. Schoenen, Delphine Magis, Francesco Pierelli, Gianluca Coppola

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Abstract

Results In both the blinded and the non-blinded analysis VEP habituation was normal in HV (slope -0.12 & -0.2 respectively), but deficient in both migraine groups: MO (+0.02 & +0.09), MA (+0.03 & +0.03). The difference between HV and MO or MA was significant for the blinded (p = 0.03 or p = 0.001) and the non-blinded procedure–(p = 0.03 or p = 0.003). Ictal VEP habituation was normal in both blinded and the non-blinded analyses (-0.21 & -0.23; p = 0.001 vs. interictal). Intraindividual habituation slope was similar between blinded and non-blinded analyses. Data obtained by non-blinded and the blinded procedure significantly correlated (overall R = 0.780. p < 0.0000001).

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Results In both the blinded and the non-blinded analysis VEP habituation was normal in HV (slope -0.12 & -0.2 respectively), but deficient in both migraine groups: MO (+0.02 & +0.09), MA (+0.03 & +0.03). The difference between HV and MO or MA was significant for the blinded (p = 0.03 or p = 0.001) and the non-blinded procedure–(p = 0.03 or p = 0.003). Ictal VEP habituation was normal in both blinded and the non-blinded analyses (-0.21 & -0.23; p = 0.001 vs. interictal). Intraindividual habituation slope was similar between blinded and non-blinded analyses. Data obtained by non-blinded and the blinded procedure significantly correlated (overall R = 0.780. p < 0.0000001).

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Available abstract

Results In both the blinded and the non-blinded analysis VEP habituation was normal in HV (slope -0.12 & -0.2 respectively), but deficient in both migraine groups: MO (+0.02 & +0.09), MA (+0.03 & +0.03). The difference between HV and MO or MA was significant for the blinded (p = 0.03 or p = 0.001) and the non-blinded procedure–(p = 0.03 or p = 0.003). Ictal VEP habituation was normal in both blinded and the non-blinded analyses (-0.21 & -0.23; p = 0.001 vs. interictal). Intraindividual habituation slope was similar between blinded and non-blinded analyses. Data obtained by non-blinded and the blinded procedure significantly correlated (overall R = 0.780. p < 0.0000001).

Key concepts: Blinded study, Habituation, Medicine, Double blinded, Migraine, Ictal, Internal medicine, Anesthesia

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EHMTI-0222. Habituation of visual evoked potentials in migraine: comparison between blinded and non-blinded analyses — Research Paper | ScholarLens