Histamine in the Human Eye

Various ocular structures (iris, ciliary body, choroid, retina, sclera, optic nerve) were enucleated from human eyes suffering endophthalmitis, perforative wounds of cornea and/or sclera, or uncontrolled glaucoma, and were tested for their histamine content. All of the tested tissues contained histamine with the highest and the lowest values always found in the uvea and retina, respectively. The eyes of the 'endophthalmitis' group showed histamine levels 5-10 times higher than amine levels found in the traumatized eyes, whereas the eyes of the 'glaucoma' group were characterized by intermediate amine contents.