Industrial Applications of Ultrafiltration in Pharmaceutical Biotechnology
Frank Lipnizki
Abstract
Frank Lipnizki
Abstract
Ultrafiltration with diafiltration is a state‐of‐the‐art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration – batch, continuous and counter‐current – and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will be discussed from both technical and economical aspects.
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Ultrafiltration with diafiltration is a state‐of‐the‐art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration – batch, continuous and counter‐current – and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will be discussed from both technical and economical aspects.
Key concepts: Diafiltration, Ultrafiltration (renal), Biochemical engineering, Industrial biotechnology, Process engineering, Biotechnology, Process (computing), Engineering