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Industrial Applications of Ultrafiltration in Pharmaceutical Biotechnology

Frank Lipnizki

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Abstract

Ultrafiltration with diafiltration is a state‐of‐the‐art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration – batch, continuous and counter‐current – and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will be discussed from both technical and economical aspects.

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What this paper is about

Ultrafiltration with diafiltration is a state‐of‐the‐art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration – batch, continuous and counter‐current – and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will be discussed from both technical and economical aspects.

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OpenAlex reports 18 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

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Available abstract

Ultrafiltration with diafiltration is a state‐of‐the‐art process used to separate solutions containing high and low molecular weight solutes. The focus of this paper is on the different concepts of ultrafiltration with diafiltration – batch, continuous and counter‐current – and the potential realization of diafiltration on an industrial scale in pharmaceutical biotechnology. Two case studies will be discussed from both technical and economical aspects.

Key concepts: Diafiltration, Ultrafiltration (renal), Biochemical engineering, Industrial biotechnology, Process engineering, Biotechnology, Process (computing), Engineering

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