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2002•The American Journal of Surgical PathologyRequires access

COL1A1-PDGFB Gene Fusion Demonstrates a Common Histogenetic Origin for Dermatofibrosarcoma Protuberans and Its Granular Cell Variant

Georges Maire, Florence Pédeutour, Jean‐Michel Coindre

Open publisher page 46 citations

Abstract

Granular cell variant of dermatofibrosarcoma protuberans is very rare with only one report of two cases. We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue. This case analysis demonstrated the utility of molecular genetics as a powerful tool for the diagnosis of atypical forms of dermatofibrosarcoma protuberans.

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What this paper is about

Granular cell variant of dermatofibrosarcoma protuberans is very rare with only one report of two cases. We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue. This case analysis demonstrated the utility of molecular genetics as a powerful tool for the diagnosis of atypical forms of dermatofibrosarcoma protuberans.

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OpenAlex reports 46 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Granular cell variant of dermatofibrosarcoma protuberans is very rare with only one report of two cases. We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue. This case analysis demonstrated the utility of molecular genetics as a powerful tool for the diagnosis of atypical forms of dermatofibrosarcoma protuberans.

Key concepts: Dermatofibrosarcoma protuberans, PDGFB, Dermatofibrosarcoma, Fusion gene, Granular cell, Biology, Gene, Genetics

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COL1A1-PDGFB Gene Fusion Demonstrates a Common Histogenetic Origin for Dermatofibrosarcoma Protuberans and Its Granular Cell Variant — Research Paper | ScholarLens