2006•Journal of Clinical MicrobiologyOpen access

Performance of Human Immunodeficiency Virus Type 1 gp41 Assays for Detecting Enfuvirtide (T-20) Resistance Mutations

Michelle Marcial, Jing Lü, Steven G. Deeks, Rainer Ziermann, Daniel R. Kuritzkes

Abstract

The performance of a gp41 assay, created using reagents designed for use with the OpenGene DNA Sequencing System, was evaluated using a panel of plasma samples obtained from enfuvirtide-naive and -experienced human immunodeficiency virus type 1-infected subjects. Resulting sequence data were highly accurate compared to a "home brew" assay and clonal sequence analysis.

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Key concepts: Enfuvirtide, Gp41, Virology, Biology, Human immunodeficiency virus (HIV), Lentivirus, Sequence (biology), Mutation