2013•AngiologyRequires access
The Effect of Exogenous Creatine Phosphate on Myocardial Injury After Percutaneous Coronary Intervention
Deng Ke-Wu, Shi Xubo, Yingxin Zhao, Shiwei Yang, Zhou Yujie, Shi Dong-Mei, Liu Yu-Yang, Jia Dean, Zhe Fang, Zhou Zhi-Ming, Hailong Ge, Y. Zhenxian, Changsheng Ma
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Abstract
OBJECTIVE: To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI). METHOD: Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3. RESULTS: Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively). CONCLUSION: Exogenous CP was helpful to reduce myocardial injury after PCI.