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Improved Power of Sib-Pair Linkage Analysis Using Measures of Complex Trait Dynamics

Jason H. Moore

Abstract

The influence of epistasis on a quantitative trait can reduce the power of linkage analysis to identify the underlying loci. In the present study, we simulated a complex trait derived from a dynamic one-locus gene expression system with epistasis arising from feedback regulation and tested the power of sib-pair linkage analysis methods for detecting the underlying quantitative trait locus (QTL). Using this simple genetic architecture, we demonstrate that the power of sib-pair linkage analysis can be greatly improved if measures of complex trait dynamics are considered.

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Key concepts: Epistasis, Quantitative trait locus, Trait, Genetic linkage, Genetic architecture, Genetics, Linkage (software), Biology