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1991•Journal of Cardiovascular ElectrophysiologyRequires access

Ionic Current in Sinoatrial Node Cells

Hiroshi Irisawa, Nobuhisa Hagiwara

Open publisher page 14 citations

Abstract

Ionic Current in Sinoatrial Node Cells. In this article, we report our current understanding of ionic mechanisms of the spontaneous rhythm of the mammalian sinoatrial pacemaker cells obtained from whole‐cell voltage clamp studies. Various ionic currents that underlie the pacemaker potential are discussed. Calcium (Ca) current, delayed‐rectifier potassium (K) current, and hyperpolarization‐activated inward current were found to be the major time‐dependent currents responsible for the pacemaker depolarization. Together with these time‐dependent currents, a time‐independent background current may also contribute to generation of pacemaker activity.

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Ionic Current in Sinoatrial Node Cells. In this article, we report our current understanding of ionic mechanisms of the spontaneous rhythm of the mammalian sinoatrial pacemaker cells obtained from whole‐cell voltage clamp studies. Various ionic currents that underlie the pacemaker potential are discussed. Calcium (Ca) current, delayed‐rectifier potassium (K) current, and hyperpolarization‐activated inward current were found to be the major time‐dependent currents responsible for the pacemaker depolarization. Together with these time‐dependent currents, a time‐independent background current may also contribute to generation of pacemaker activity.

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Available abstract

Ionic Current in Sinoatrial Node Cells. In this article, we report our current understanding of ionic mechanisms of the spontaneous rhythm of the mammalian sinoatrial pacemaker cells obtained from whole‐cell voltage clamp studies. Various ionic currents that underlie the pacemaker potential are discussed. Calcium (Ca) current, delayed‐rectifier potassium (K) current, and hyperpolarization‐activated inward current were found to be the major time‐dependent currents responsible for the pacemaker depolarization. Together with these time‐dependent currents, a time‐independent background current may also contribute to generation of pacemaker activity.

Key concepts: Sinoatrial node, Pacemaker potential, Depolarization, Medicine, Current (fluid), Hyperpolarization (physics), Electrophysiology, Biophysics

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