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Effects of Sodium Nitroprusside and Other Pentacyanonitrosyl Complexes on Platelet Aggregation

Erika Glusa, F Markwárdt, Jörg Stürzebecher

Abstract

The influence of sodium nitroprusside (SNP) and other nitric oxide complexes on platelet function is studied. SNP inhibits platelet aggregation and the release reaction, while pentacyanonitrosyl complexes of manganese, tungsten, and molybdenum are ineffective. Since nitrosylperchlorate exerts the same inhibitory effect on platelet aggregation the nitrosyl cation is supposed to be the constituent of SNP responsible for inhibition.

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Key concepts: Sodium nitroprusside, Chemistry, Platelet aggregation, Nitric oxide, Platelet, Biophysics, SNP, Manganese