An Evaluation of the Toxicity of Adrenaline, Isoprenaline, and Terbutaline after Pretreatment with Isoprenaline and Terbutaline

The toxic effects of adrenaline, isoprenaline, and terbutaline have been determined in mice after pretreatment of the animals with isoprenaline, terbutaline, and saline solution (control). Pretreatment with isoprenaline and terbutaline was without any significant effect on the mortality (LD 50) due to isoprenaline and terbutaline. The sensitivity to adrenaline, however, was considerably increased after pretreatment with isoprenaline but only slightly after terbutaline.