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1970•The Journal of Clinical Endocrinology & MetabolismRequires access

STIMULATION OF RELEASE OF THYROID IODINE BY SERUM OF THYROID-IMMUNIZED RABBITS

David H. Solomon, Gildon N. Beall, INDER J. CHOPRA

Open publisher page 9 citations

Abstract

ABSTRACT A double-isotopic modification of the McKenzie assay has been devised. The serum of certain rabbits immunized with human thyroid microsomes caused true thyroid iodine release in the test mice, but also induced a marked shift of labeled T4 from tissues into plasma. This accounted for some of the apparent “thyroid stimulation” seen in the standard McKenzie assay of such sera. In the case of many thyroid-immunized sera of lower activity, the double-isotopic method revealed that thyroid stimulation was nonexistent.

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ABSTRACT A double-isotopic modification of the McKenzie assay has been devised. The serum of certain rabbits immunized with human thyroid microsomes caused true thyroid iodine release in the test mice, but also induced a marked shift of labeled T4 from tissues into plasma. This accounted for some of the apparent “thyroid stimulation” seen in the standard McKenzie assay of such sera. In the case of many thyroid-immunized sera of lower activity, the double-isotopic method revealed that thyroid stimulation was nonexistent.

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Available abstract

ABSTRACT A double-isotopic modification of the McKenzie assay has been devised. The serum of certain rabbits immunized with human thyroid microsomes caused true thyroid iodine release in the test mice, but also induced a marked shift of labeled T4 from tissues into plasma. This accounted for some of the apparent “thyroid stimulation” seen in the standard McKenzie assay of such sera. In the case of many thyroid-immunized sera of lower activity, the double-isotopic method revealed that thyroid stimulation was nonexistent.

Key concepts: Thyroid, Stimulation, Iodine, Endocrinology, Internal medicine, Chemistry, Microsome, Medicine

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STIMULATION OF RELEASE OF THYROID IODINE BY SERUM OF THYROID-IMMUNIZED RABBITS — Research Paper | ScholarLens