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1998•Angewandte Chemie International EditionRequires access

Dual Recognition of Double-Stranded DNA by 2′-Aminoethoxy-Modified Oligonucleotides

Bernard M. Cuenoud, Florence Casset, Dieter Hüsken, François Natt, Romain M. Wolf, Karl‐Heinz Altmann, Pierre Martin, Heinz E. Moser

Open publisher page 129 citations

Abstract

Simultaneous interaction of the 2'-aminoethoxy-modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base-pair step of the duplex DNA target. The electrostatic interaction between the protonated amino group and the negatively charged phosphate group provides for a dramatic increase in the binding affinity and the association rate constant.

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What this paper is about

Simultaneous interaction of the 2'-aminoethoxy-modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base-pair step of the duplex DNA target. The electrostatic interaction between the protonated amino group and the negatively charged phosphate group provides for a dramatic increase in the binding affinity and the association rate constant.

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OpenAlex reports 129 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Simultaneous interaction of the 2'-aminoethoxy-modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base-pair step of the duplex DNA target. The electrostatic interaction between the protonated amino group and the negatively charged phosphate group provides for a dramatic increase in the binding affinity and the association rate constant.

Key concepts: Oligonucleotide, DNA, Dual (grammatical number), Computational biology, Biology, Chemistry, Genetics, Philosophy

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