1974•EndocrinologyRequires access

Parathyroid Function in the Alloxan Diabetic Rat

Louis E. Schneider, GARY K. HARGIS, Harold P. Schedl, GERALD A. WILLIAMS

Abstract

Serum immunoreactive parathyroid hormone (IPTH) was measured in control and in alloxan-induced diabetic rats ingesting a normal calcium diet and in control rats ingesting a low calcium diet. Serum IPTH levels in controls ingesting the low calcium diet were three times those of controls on the normal calcium diet. Serum IPTH in diabetic rats was double that in controls. Therefore,the diabetic rat manifests an appropriate parathyroid response to diminished calcium absorption. The deficiency of duodenal calcium binding protein and the duodenal calcium malabsorption previously observed in diabetic rats are not the result of a defect in PTH regulation of vitamin D metabolism. (En-docrinology95: 749, 1974)

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Key concepts: Internal medicine, Endocrinology, Calcium, Alloxan, Parathyroid hormone, Malabsorption, Calcium metabolism, Medicine