2009•International Journal of Biological and Chemical SciencesOpen access
Antinociceptive, antipyretic and anti-inflammatory effects of Clerodendrum phlomidis in mice and rats
D. Kilimozhi, V. Parthasarathy, MN Jayant, R. Manavalan
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Abstract
The ethanolic extract of Clerodendrum phlomidis L. belonging to the family of Verbenaceae was evaluated for its antinociceptive, antipyretic and anti-inflammatory activity in mice and rats respectively. Analgesic activity was studied by using acetic acid-induced mouse withering test, hot water tail immersion method and eddy’s hot plate method in mice. The antipyretic activity was evaluated against yeast induced pyroxia in rat and anti-inflammatory activity was evaluated by carrageenan-induced hind paw edema and its probable mechanism evaluated in rats. The preliminary phytochemical screening and acute toxicity studies were carried out. C. phlomidis extract showed a dose dependent significant reduction of the number of writhes (P
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