1965•Journal of Pharmacy and PharmacologyRequires access

Effect of adrenalectomy on cotton pellet granuloma formation in the rat

A. Ashford, G B Penn

Abstract

Abstract The development of granulomas over 3 days was inhibited in adrenalectomised rats when cotton pellets were implanted on the day of adrenalectomy and was potentiated when the pellets were implanted 7 days after adrenalectomy. The initial inhibitory effect of adrenalectomy was not observed when the granulomas were allowed to remain in situ for 7 days instead of 3 days and was completely reversed by treatment with corticosterone.

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Available abstract

Key concepts: Adrenalectomy, Corticosterone, Pellets, Granuloma, Bilateral adrenalectomy, Pellet, Granuloma formation, Medicine