1982•Antimicrobial Agents and ChemotherapyOpen access
Comparative biliary excretion of cephalosporins in normal and partially hepatectomized rats
N.L. Humphries, D G Tasker, S. J. Karran
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Abstract
The biliary excretion of six cephalosporins was examined in normal and partially hepatectomized rats. Cefamandole, cefazolin, cefuroxime, cefoxitin, and cephradine were excreted well in normal animals. In partially hepatectomized rats, the cumulative percentage of excretion reached only 11 to 36.8% of the control levels. Cephaloridine was excreted poorly in both groups.