Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions

The coordination complexes of bivalent metal ions with N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide (H2bmctz, H2L-1) and N-[(1E)-1-(1H-Benzimidazol-2-yl)(phenyl)methylidene] morpholine-4-carbothiohydrazide (H2bpmctz, H2L-2) were prepared and their neutral, monoanionic, and dianionic forms of ligands of compositions [M(H2L)X2] (M= CoII , NiII , CuII , ZnII , CdII , or PdII , X=Cl−or Br−, and H2L=H2L-1 or H2L-2), [M(HL)2]nH2O where (M= CoII , CuII , MnII , NiII , ZnII or CdII , H2L=H2L-1 or H2L-2, andn= 0 or 2), and [MLB]nB (M= CuII , NiII , ZnII , CdII , or PdII , B=H2O, Py, or Y -pic,n= 0 andn= 1 if B=H2O for Ni(II) and H2L=H2L-1 or H2L-2) have been characterised by magnetic susceptibility measurements, electrical conductance values, and spectral properties. The magnetic moment value of [M(HL2)] (M= MnII , NiII , FeII or CuII ) type complexes is consistent with high spin octahedral structure while those of [M(H2L)X2] (M= CoII , NiII , CuII , ZnII , or CdII , X=Cl−or Br−) possess five coordinated trigonal bipyramidal geometry. The adduct complexes [MLB]·nB (M= NiII , or CuII , B=H2O, Py, or Y -pic) are four coordinated planar and those of ZnII and CdII complexes [MLB], (H2L=H2L-1 or H2L-2, B=H2O, Py or Y -pic) are tetrahedral. These ligands have been suggested to coordinate as tridentate (N N S) donor molecule in complexes of type [M(H2L)X2], [M(HL)2], and [MLB]. The antifungal activity of ligands and some of their metal complexes were studied and it was observed that metal complexes show higher activity than free ligand.