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2013•Emerging infectious diseasesOpen access

Human Granulocytic Anaplasmosis, Japan

Norio Ohashi, Gaowa, Fumihiko Wuritu, Dongxing Kawamori, Yuko Wu, Seizou Yoshikawa, Kazutoshi Chiya, Toyohiko Fukunaga, Masaaki Funato, Shiojiri, Hideki Nakajima, Yoshiji Hamauzu, Ai Takano, Hiroki Kawabata, Shuji Ando, Toshio Kishimoto

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Abstract

We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. phagocytophilum antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used for serodiagnosis of rickettsiosis-like infections, cases of human granulocytic anaplasmosis could go undetected.

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What this paper is about

We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. phagocytophilum antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used for serodiagnosis of rickettsiosis-like infections, cases of human granulocytic anaplasmosis could go undetected.

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Available abstract

We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. phagocytophilum antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used for serodiagnosis of rickettsiosis-like infections, cases of human granulocytic anaplasmosis could go undetected.

Key concepts: Anaplasma phagocytophilum, Anaplasmosis, Anaplasma, Rickettsiosis, Virology, Anaplasmataceae, Tick-borne disease, Biology

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