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2007•Pediatric TransplantationOpen access

Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid‐free rabbit anti‐human thymocyte globulin

Anjan Kumar Talukdar, Chethan Ashokkumar, Jennifer L. Farrar, Patrick Wilson, Arun Janakiramanan, Mary Tregaskes, Rakesh Sindhi

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Abstract

Multiple measurements of lymphocyte subsets in 91 children treated with steroid-free tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection-prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.

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What this paper is about

Multiple measurements of lymphocyte subsets in 91 children treated with steroid-free tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection-prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.

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OpenAlex reports 11 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Multiple measurements of lymphocyte subsets in 91 children treated with steroid-free tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic cells, and gradual reconstitution of all other subsets, which is complete after one yr. Rejection-prone children demonstrate significantly higher counts of lymphocytes and all subsets prior to liver transplantation, and may exemplify one basis for enhanced baseline immunocompetence.

Key concepts: Anti-thymocyte globulin, Immunocompetence, Thymocyte, Medicine, Tacrolimus, Lymphocyte subsets, Immunology, Cytotoxic T cell

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