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2011•Emerging infectious diseasesOpen access

Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa

N. Sarita Shah, Jessica W. Richardson, Prashini Moodley, Salona Moodley, Palav Babaria, Melissa A. Ramtahal, Scott Kirkland Heysell, Xuan Li, Anthony P. Moll, GERALD H. FRIEDLAND, A. Willem Sturm, Neel R. Gandhi

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Abstract

We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa.Of 19 patients with extensively drug-resistant TB identifi ed during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested.This resistance leaves no effective treatment with available drugs in South Africa. The StudyThis study was conducted in Tugela Ferry, South Africa, where TB incidence is ≈1,100 cases/100,000 population and >80% of TB case-patients are HIV infected.

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We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa.Of 19 patients with extensively drug-resistant TB identifi ed during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested.This resistance leaves no effective treatment with available drugs in South Africa. The StudyThis study was conducted in Tugela Ferry, South Africa, where TB incidence is ≈1,100 cases/100,000 population and >80% of TB case-patients are HIV infected.

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Available abstract

We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa.Of 19 patients with extensively drug-resistant TB identifi ed during February 2008-April 2009, 13 (68%) had isolates resistant to all 8 drugs tested.This resistance leaves no effective treatment with available drugs in South Africa. The StudyThis study was conducted in Tugela Ferry, South Africa, where TB incidence is ≈1,100 cases/100,000 population and >80% of TB case-patients are HIV infected.

Key concepts: Tuberculosis, Drug resistance, Drug, Mycobacterium tuberculosis, Extensively drug-resistant tuberculosis, Medicine, Drug resistant tuberculosis, Virology

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