1985•Clinical Infectious DiseasesRequires access

Activity of Imipenem Against Pseudomonas and Bacteroides Species

John D. Williams

Abstract

The activity of imipenem against Pseudomonas aeruginosa and Bacteroides fragilis in vitro was studied. MICs of imipenem for P. aeruginosa are approximately 2 micrograms/m. Unlike most other beta-lactam antibiotics, imipenem does not show cross-resistance in the presence of intrinsic resistance. Imipenem is a strong inducer of Id beta-lactamase but is stable to hydrolysis by this enzyme. B. fragilis is more susceptible to imipenem than to other beta-lactam antibiotics. The activity of imipenem against B. fragilis is similar to that of metronidazole. The cephalosporinases of B. fragilis do not inactivate imipenem.

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Key concepts: Imipenem, Bacteroides fragilis, Microbiology, Pseudomonas aeruginosa, Bacteroidaceae, Antibiotics, Bacteroides, Antibacterial agent